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Steroidogenic factor 1 : ウィキペディア英語版 | Steroidogenic factor 1
The steroidogenic factor 1 (SF1) protein controls sexual development in the embryo and at puberty. SF1 is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the ''NR5A1'' gene (nuclear receptor subfamily 5, group A, member 1). == Function ==
SF-1 is a critical regulator of reproduction, regulating the transcription of key genes involved in sexual development and reproduction, most notably StAR and P450SCC. It can form a transcriptional complex with TDF to up-regulate transcription of the Sox9 gene. Its targets include genes at every level of the hypothalamic-pituitary-gonadal axis, as well as many genes involved in gonadal and adrenal steroidogenesis.
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